Hotels in Saint Louis Center

Not Just Any Hotel – Only the Best Hotels in Saint Louis Center, Selected for You!

Saint Louis

Feb 24, 2025 - Feb 25, 2025

2 adults, 1 room

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United States Hotels

Missouri Hotels

Hotels in Saint Louis Center

Price per night: Price / night

Up to 100$

$100 - 200

From $200

Rating: Guest rating

Excellent 9+

Very good 8+

Good 7+

All ratings

Star rating: Star rating

5-stars

4-stars

3-stars

Unrated

Very good (116)

The Last Hotel

View map · 0.5 mi City Centre

From

169US$ /per night

8.2

Very good (37)

21C Museum Hotel St Louis

View map · 0.4 mi City Centre

From

197US$ /per night

8.2

Very good (57)

Live! By Loews - St. Louis

View map · 1.0 mi City Centre

From

259US$ /per night

8.6

Excellent (391)

Hilton St. Louis At The Ballpark

View map · 0.7 mi City Centre

From

98US$ /per night

8.2

Very good (182)

Marriott St. Louis Grand

View map · 0.7 mi City Centre

From

109US$ /per night

8.4

Very good (158)

The Moonrise Hotel

View map · 5.5 mi City Centre

From

294US$ /per night

8.6

Excellent (143)

The Westin St. Louis

View map · 0.5 mi City Centre

From

129US$ /per night

8.2

Very good (51)

Courtyard By Marriott St. Louis West County

View map · 13.7 mi City Centre

From

159US$ /per night

8.2

Very good (139)

Oyo Hotel St Louis Downtown City Center Mo

View map · 0.1 mi City Centre

From

102US$ /per night

8.4

Very good (50)

Hotel Saint Louis, Autograph Collection

View map · 0.6 mi City Centre

From

274US$ /per night

8.2

Very good (71)

Comfort Suites St Louis - Sunset Hills

View map · 12.1 mi City Centre

From

134US$ /per night

Very good (97)

Hotelumiere At The Arch

View map · 1.1 mi City Centre

From

109US$ /per night

8.4

Very good (231)

Pear Tree Inn St Louis Convention Center

View map · 0.9 mi City Centre

From

190US$ /per night

8.2

Very good (74)

Holiday Inn St Louis Sw - Route 66, An Ihg Hotel

View map · 12.1 mi City Centre

From

152US$ /per night

8.4

Very good (69)

Courtyard By Marriott St. Louis Downtown West

View map · 0.7 mi City Centre

From

118US$ /per night

8.8

Excellent (107)

Residence Inn By Marriott St. Louis Downtown

View map · 0.9 mi City Centre

From

148US$ /per night

7.4

Good (34)

Home2 Suites By Hilton St Louis Downtown

View map · 0.4 mi City Centre

From

146US$ /per night

8.4

Very good (321)

La Quinta By Wyndham St. Louis Westport

View map · 13.4 mi City Centre

From

74US$ /per night

8.4

Very good (71)

The Cheshire

View map · 5.6 mi City Centre

From

119US$ /per night

8.6

Excellent (116)

Drury Inn & Suites St. Louis Forest Park

View map · 4.7 mi City Centre

From

110US$ /per night

8.4

Very good (30)

Residence Inn By Marriott St. Louis West County

View map · 13.7 mi City Centre

From

264US$ /per night

8.6

Excellent (109)

Four Seasons St. Louis

View map · 1.1 mi City Centre

From

319US$ /per night

8.4

Very good (161)

Drury Inn And Suites St Louis Union Station

View map · 0.4 mi City Centre

From

141US$ /per night

8.4

Very good (31)

Ac Hotel By Marriott St Louis Central West End

View map · 3.5 mi City Centre

From

204US$ /per night

8.2

Very good (36)

Aloft St. Louis Cortex

View map · 2.7 mi City Centre

From

159US$ /per night

8.2

Very good (113)

Angad Arts Hotel

View map · 1.7 mi City Centre

From

160US$ /per night

8.4

Very good (81)

Doubletree By Hilton St. Louis At Westport

View map · 14.1 mi City Centre

From

169US$ /per night

8.4

Very good (132)

Best Western St Louis Kirkwood Route 66

View map · 11.8 mi City Centre

From

86US$ /per night

8.2

Very good (103)

Super 8 By Wyndham St. Louis North

View map · 4.2 mi City Centre

From

90US$ /per night

8.4

Very good (94)

Holiday Inn Express St. Louis Central West End, An Ihg Hotel

View map · 3.3 mi City Centre

From

142US$ /per night

8.4

Very good (393)

Pear Tree Inn St. Louis Near Union Station

View map · 0.6 mi City Centre

From

100US$ /per night

8.6

Excellent (136)

Doubletree By Hilton St. Louis Forest Park

View map · 3.2 mi City Centre

From

128US$ /per night

8.4

Very good (99)

The Royal Sonesta Chase Park Plaza

View map · 3.6 mi City Centre

From

207US$ /per night

8.4

Very good (214)

Holiday Inn St Louis Downtown/Convention Center, An Ihg Hotel

View map · 0.7 mi City Centre

From

144US$ /per night

8.4

Very good (415)

Hyatt Regency Saint Louis At The Arch

View map · 0.8 mi City Centre

From

99US$ /per night

7.8

Very good (30)

Element St. Louis Midtown

View map · 2.1 mi City Centre

From

139US$ /per night

8.6

Excellent (165)

Hampton Inn & Suites St. Louis At Forest Park

View map · 4.2 mi City Centre

From

219US$ /per night

8.6

Excellent (59)

Courtyard St. Louis Downtown/Convention Center

View map · 0.7 mi City Centre

From

190US$ /per night

7.8

Very good (147)

Americas Best Value Inn St. Louis Downtown

View map · 1.1 mi City Centre

From

62US$ /per night

8.6

Excellent (586)

Drury Plaza St. Louis At The Arch

View map · 0.8 mi City Centre

From

110US$ /per night

8.6

Excellent (103)

Le Meridien St. Louis Downtown

View map · 0.4 mi City Centre

From

424US$ /per night

7.6

Very good (81)

Days Inn By Wyndham Downtown St. Louis

View map · 1.9 mi City Centre

From

124US$ /per night

8.4

Very good (76)

Saint Louis Airport Hotel

View map · 10.3 mi City Centre

From

112US$ /per night

7.6

Very good (28)

Tru By Hilton St Louis Downtown Mo

View map · 0.4 mi City Centre

From

144US$ /per night

7.8

Very good (45)

Hotel Indigo - St. Louis - Downtown, An Ihg Hotel

View map · 0.7 mi City Centre

From

202US$ /per night

8.4

Very good (57)

Magnolia Hotel St. Louis, A Tribute Portfolio Hotel

View map · 0.6 mi City Centre

From

154US$ /per night

8.2

Very good (142)

Red Roof Inn St Louis - Westport

View map · 13.6 mi City Centre

From

47US$ /per night

8.6

Excellent (406)

Hampton Inn St Louis- At The Arch

View map · 0.9 mi City Centre

From

209US$ /per night

8.4

Very good (95)

Embassy Suites Saint Louis - Downtown

View map · 0.7 mi City Centre

From

114US$ /per night

8.4

Very good (64)

Best Western Plus St. Louis Airport Hotel

View map · 11.1 mi City Centre

From

47US$ /per night

8.2

Very good (73)

Fairfield Inn And Suites By Marriott St Louis Downtown

View map · 0.6 mi City Centre

From

164US$ /per night

8.6

Excellent (38)

Lehmann House Bed & Breakfast

View map · 0.8 mi City Centre

From

206US$ /per night

8.2

Very good (51)

Casa Magnolia B & B

View map · 3.0 mi City Centre

From

190US$ /per night

8.6

Excellent (64)

Seven Gables Inn, St Louis West, A Tribute Portfolio Hotel

View map · 7.6 mi City Centre

From

139US$ /per night

8.2

Very good (219)

Missouri Athletic Club

View map · 0.9 mi City Centre

From

104US$ /per night

8.2

Very good (148)

La Quinta Inn & Suites By Wyndham St Louis Route 66

View map · 12.0 mi City Centre

From

80US$ /per night

8.2

Very good (157)

St. Louis Union Station Hotel, Curio Collection By Hilton

View map · 0.3 mi City Centre

From

150US$ /per night

8.2

Very good (163)

The Pennywell St.Louis Downtown, A Hilton Hotel

View map · 0.8 mi City Centre

From

109US$ /per night

8.6

Excellent (92)

Hampton Inn & Suites - Saint Louis South Interstate 55

View map · 12.7 mi City Centre

From

199US$ /per night

8.4

Very good (50)

City Place Hotel

View map · 0.8 mi City Centre

From

107US$ /per night

Discover Your Perfect Stay

Saint Louis, often referred to as the Gateway to the West, is a vibrant city that seamlessly blends rich history with modern attractions. For travelers seeking an unforgettable experience, the downtown area is home to a selection of luxurious 5 star hotels that provide the perfect base for exploring all that the city has to offer. From stunning views of the iconic Gateway Arch to proximity to world-class dining and entertainment, these accommodations elevate your visit to new heights.

When it comes to indulging in comfort and elegance, the 5 star hotels in St Louis Downtown set the standard high. Guests are welcomed with opulent amenities, personalized service, and exquisite dining options, making each stay a memorable one. Whether you’re in town for business or leisure, these hotels are designed to cater to every need, ensuring a lavish getaway in the heart of the city.

In addition to exceptional hospitality, downtown St Louis boasts a wealth of attractions just moments away from these luxurious accommodations. Enjoy leisurely strolls through beautiful parks, immerse yourself in the rich cultural scene, or experience thrilling sporting events—all within easy reach. Choosing a 5 star hotel in St Louis Downtown allows you to experience the very best the city has to offer, providing a blend of relaxation and adventure that will leave you longing to return.

Name of hotel	Accommodation Rating	Price, $
Hyatt Regency Saint Louis At The Arch	7.9 / 10 (3631 Reviews)	From 99US$
Hotel Saint Louis, Autograph Collection	8.6 / 10 (100 Reviews)	From 274US$
21C Museum Hotel St. Louis	8.7 / 10 (677 Reviews)	From 197US$
Four Seasons St. Louis	8.6 / 10 (88 Reviews)	From 319US$

Hyatt Regency Saint Louis At The Arch

315 Chestnut Street

The Hyatt Regency Saint Louis At The Arch offers a perfect blend of modern luxury and historic charm, making it a standout among the 5 star hotels in St Louis Downtown. Located right next to the famous Gateway Arch, guests can easily immerse themselves in the rich history of the area. The hotel's elegant rooms feature floor-to-ceiling windows, allowing for breathtaking views of the Arch and the downtown skyline. An array of dining options, including a vibrant rooftop bar, ensures that guests have a variety of culinary experiences at their fingertips. The expansive fitness center and indoor pool further enhance the wellness offerings at this delightful hotel. With a commitment to exceptional service and convenience, the Hyatt Regency provides an unforgettable stay in St Louis.

From

99US$ /per night

Hotel Saint Louis, Autograph Collection

705 Olive Street

The Hotel Saint Louis, part of the prestigious Autograph Collection, stands out as a luxurious option among the 5 star hotels in St Louis Downtown. This historic hotel, housed in the former home of the renowned St Louis Club, has been stunningly restored to showcase its architectural grandeur. Rooms are tastefully decorated to provide a seamless blend of modern comfort and classic elegance, complete with premium furnishings and artisan details. Guests can indulge in seasonal cuisine at the hotel’s acclaimed restaurant and enjoy handcrafted cocktails at the rooftop bar with spectacular city views. Additionally, the prime downtown location places guests within walking distance of major attractions, shopping, and entertainment. With a focus on personalized service and extraordinary experiences, the Hotel Saint Louis promises an unforgettable stay for all who visit.

From

274US$ /per night

5 Star Hotels in St. Louis Downtown

In the heart of St Louis, luxury is defined by a selection of exquisite 5 star hotels that cater to discerning travelers. These hotels not only offer opulent accommodations but also create unique experiences that showcase the city's vibrant culture and history. Each property is strategically located, providing guests with easy access to iconic attractions and business hubs. From sumptuous spa treatments to gourmet dining and stunning views of the Gateway Arch, these establishments embody the essence of sophisticated urban living. For those seeking a memorable getaway, the 5 star hotels in St Louis Downtown promise unparalleled service and indulgence. Let’s explore a few of the premier choices that define luxury in this captivating city.

21C Museum Hotel St. Louis

1528 Locust Street

For art enthusiasts and luxury seekers alike, the 21C Museum Hotel St Louis is a unique option among the 5 star hotels in St Louis Downtown. This one-of-a-kind hotel doubles as a contemporary art museum, featuring stunning installations throughout the property. Guests can enjoy spacious, thoughtfully designed rooms equipped with modern comforts and artistic flair. The hotel’s innovative dining experience at the Gray Room allows guests to savor delicious dishes while surrounded by captivating art. With a complimentary guided art tour and varied cultural events, the 21C Museum Hotel creates a dynamic atmosphere that promotes creativity and engagement. Staying here means blending luxury with a unique cultural experience, setting it apart from traditional accommodations.

From

197US$ /per night

Four Seasons St. Louis

999 North 2Nd Street

The Four Seasons St Louis stands as a beacon of elegance among the 5 star hotels in St Louis Downtown. This luxurious hotel features contemporary design elements that harmonize with its stunning riverfront location. Guests are treated to spacious rooms equipped with upscale amenities, ensuring a relaxing stay. The hotel boasts an exceptional spa and a rooftop pool that offers sweeping views of the iconic Gateway Arch and the Mississippi River. Dining options are impeccable, including the renowned Cielo Restaurant, where guests can enjoy delectable regional cuisine. Every aspect of the Four Seasons is tailored to provide an extraordinary experience for guests seeking the ultimate in comfort and style.

From

319US$ /per night

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Hotels near Landmark

• Saint Louis Zoo

• Forest Park (St. Louis)

• Saint Louis Union Station

• Gateway Arch

• Greyhound Bus Terminal

• Fox Theatre

• Edward Jones Dome

• The Pageant

• Chaifetz Arena

• Americas Center

Hotels in District

• Downtown St. Louis